2019 GA meeting May 8 in Madrid


The 2018 GA meeting which took place on Thursday 3 May 2018 in Brugge, Belgium saw an increase in attendance from 2017. Hosted by Prince-Erachem, the meeting which lasted 5 hours saw several deliberations related to the last REACH deadline and its consequences thereafter including the possible re-structuring of the consortium.  Some key decisions taken by way of vote are as follows:

Some highlights:

  • Future structure of Mara: A more streamline structure to be established if the organisation is to continue functioning infinitely or in the event of a complete closure its mandate and members to be incorporated within the Mn trade association –The IMnI. Discussions are still on-going  
  • Collaboration: A clearly defined pathway for collaboration between Mara and the IMnI was established
  • Data-sharing Regulation: Approval of the reimbursement structure (to be executed in phases) in accordance with regulation 2016/9
  • Approval of the 2018 workplan and budget

Manganese dinitrate (EC: 233-828-8; Cas: 10377-66-9)

Submitted in 2010, with no testing proposals, this substance has not undergone any aspect of the REACH evaluation process to date.

This salt is an analogue with manganese dichloride (MnCl2) which, because of its solubility and bioavailability, is often the test material choice for most academic studies which end up being published in peer-review literature. The outcome of these publications can change the hazard assessment of this dossier via read-across with its analogue MnCl2.  Hence, literature review is carried every two years. Furthermore, new information on two reproductive endpoints (two generation reproductive toxicity and pre-natal developmental toxicity) are available from the International Manganese Institute’s (IMnI) worker safety program. Both studies used MnCl2 as the test material and the information obtained from both studies is read-across to manganese dinitrate. Therefore, the information from the published literature and from those studies initiated by the IMnI will trigger a spontaneous dossier update.

An updated dossier was last submitted in December 2017. The update considered new uses and new data especially that on reproductive toxicity. This was a foresight, as ECHA's request to update this dossier in January 22, 2018 encourage the review of endpoints associated with reproductive toxicity potential - http://consortium.manganese.org/news/article/four-manganese-substances-short-listed-by-the-echa-as-substances-of-potenti. Upon the review of the December, 2017 version of the submitted dossier, the consortium considered the information in the latest dossier up-to-date. 

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