2023 Mn REACH Conference September 26-28th Thon Hotel, City Centre, Brussels

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MARA's 2023 Mn REACH Conference is scheduled to take place on September 26-28 at the Thon Hotel City Centre, Brussels.

Speakers from the Manganese Industry, other Metal Consortia, European Metal Associations and Regulatory Experts will enlighten you on the short-term risks/threats on your businesses as well as your responsibilities under the Evaluation aspect of EU REACH


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ACUTE EYE IRRITATION IN THE RABBIT/ MnSO4 (Manganese Sulphate Monohydrate)/ OECD 405 / GLP

Introduction. The study was performed to assess the irritancy potential of the test material using the model of the eye of the New Zealand white rabbit. The method was designed to meet the requirements of the following:

  • OECD Guidelines for the Testing of Chemicals No. 405, “Acute Eye Irritation/Corrosion” (adopted 24 April 2002)
  • Method B5 Acute Toxicity (Eye Irritation) of Commission Regulation (EC) No. 440/2008

Conclusion. The test material produced a maximum total score of 36 and was considered to be at least a moderate irritant (Class 5 on a 1 to 8 scale) to the rabbit eye according to a modified Kay and Calandra classification system (based on one rabbit only).

The test material was also considered to be an irritant according to EU labelling regulations Commission Directive 2001/59/EC. It is reasonable to assume that the symbol “Xi” (the indication of danger, “Irritant”) and the highest risk phase (R41, “RISK OF SERIOUS DAMAGE TO EYES”) are required here due to the evidence of irreversible ocular damage (based on one rabbit only).

To obtain the full study, please contact: reach@manganese.org.


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