ACUTE INHALATION TOXICITY IN RATS/ MnSO4 (Manganese Sulphate Monohydrate)/ OECD 403/ GLP
Introduction. A study was performed to assess the acute inhalation toxicity of the test material. The method as used followed that described in the OECD Guidelines for Testing of Chemicals (1981) No. 403 “Acute Inhalation Toxicity”, referenced as Method 82 (Inhalation) of Commission Regulation (EC) No. 440/2008.
Conclusion. No deaths occurred in a group of ten rats exposed to a mean achieved atmosphere concentration of 4.98 mg/L for 4 hours. It was therefore considered that the acute inhalation median lethal concentration (4 hr LC50) of MnSO4 in the HsdHanTM WIST strain rat was greater than 4.98 mg/L. The equivalent LC50 value for the anhydrous form of this material is considered to be >4.45mg/L.
On the basis of this result, MnSO4 does not meet the criteria for classification in the EU in accordance with both Council Directive 67/548/EEC (as amended) and Regulation (EC) No 1272/2008, and will not require labelling for inhalation toxicity.
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