ACUTE INHALATION TOXICITY STUDY IN THE RAT/ Mn metal (Manganese metal)/ OECD 403/ GLP
Introduction. A study was performed to assess the acute inhalation toxicity of the test material. The method as used followed that described in the OECD Guidelines for Testing of Chemicals (1981) No. 403, “Acute Inhalation Toxicity”, referenced as Method 82 (Inhalation) of Commission Regulation (EC) No. 440/2008.
Conclusion. No deaths occurred in a group of 10 rats exposed to a mean achieved atmosphere concentration of 5.14 mg/L for 4 hours. It was therefore concluded that the acute inhalation median lethal concentration (4 hr LC50) of Mn metal in the HsdHanTM : WIST strain rat was greater than 5.14 mg/L.
On the basis of this result, Mn metal does not meet the criteria for classification in the EU in accordance with both Council Directive 67/548/EEC (as amended) and Regulation (EC) No 1272/2008, and, accordingly, will not require labelling for inhalation toxicity.
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