ACUTE INHALATION TOXICITY STUDY IN THE RAT/ Mn3O4 (Trimanganese tetraoxide)/ OECD 403/ GLP
Introduction. A study was performed to assess the acute inhalation toxicity of the test item. The method used followed that described in the OECD Guidelines for Testing of Chemicals (2009) No. 403 “Acute Inhalation Toxicity” and was designed to comply with Method 82 (Inhalation) of Commission Regulation (EC) No. 440/2008, with the exception that only six animals (three males and three females) were utilized during the “limit test”.
Conclusion. No deaths occurred in a group of six rats exposed to a mean achieved atmosphere concentration of 5.17 mg/L for four hours. It was therefore considered that the acute inhalation median lethal concentration (4 hr LC50) of Mn3O4 (Erachem), in the HsdHanTM : WlST strain rat, was greater than 5.17 mg/L.
On the basis of this result, Mn304 (Erachem) does not meet the criteria for classification in the EU in accordance with both Council Directive 67/548/EEC as amended and Regulation (EC) No 1272/2008 and will not require labelling for inhalation toxicity.
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