General Assembly Meeting Thursday, May 5th 10:00 – 13:00

General Assembly Meeting - 2022

A virtual (Zoom) and face-to-face meeting in Paris, France

followed by Lunch

Other Logistical information to follow nearer the time

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The 2020 GA meeting which normally takes place in May was postponed to November 4th due to the global pandemic. The November 4th meeting which was virtual saw 20 attendees and lasted an hour as most of the GA mandated task/decisions were addressed by way of votes prior to the meeting. Chaired by Interim Chairman Dr Bernd Friede, the meeting though brief was effective with some key decisions taken as follows:

Some highlights:

  • Executive Committee: A new Executive team was endorsed with the 2nd Vice-Chairman becoming the Chairman and Secretary General maintained to ensure continuity
  • Non-EU letter of Access Fees: Letter of Access fees and administration fees for non-EU REACH-Like regulations per substance, per legal entity for non-MARA members was established
  • Members involvement in Non-EU regulations: MARA members wishing to register substances in non-EU REACH-like regulations will only pay administration fees as they own the data generated by MARA
  • Technical update: Three dossiers updated this year lead to a new classification for manganese based UVCB’s
  • 2020 Workplan and budget were ratified in Q1, 2020 via round robin votes.

DAPHNID, CERIODAPHNIA DUBIA SURVIVAL AND REPRODUCTION TEST/ Mn metal (Manganese metal)/OECD 211/GLP

Introduction. A study was performed to assess the effect of the test item on the survival and reproduction of Ceriodaphnia dubia over an 8-Day period. The method followed that described in the OECD Guidelines for Testing of Chemicals No 211 (1998), "Daphnia magna, Reproduction Test", US EPA Short-term Methods for Estimating the Chronic Toxicity of Effluents and Receiving Waters to Freshwater Organisms (Method 1002.0), and OPPTS Ecological Effects Test Guideline (Daphnid Chronic Toxicity Test OPPTS 850.1300).

Results. Analysis of the fresh test preparations on Days 0, 3, 5 and 7 showed measured concentrations to range from 0.353 to 8.15 mg/l as the test item. Analysis of the old media on Days 3, 5, 7 and 8 showed measured concentrations to range from 0.369 to 8.36 mg/l as the test item.

Given that no decline in measured concentration was observed over each media renewal period, the results were based on the mean measured test concentration as a test item only. These were calculated to be 0.52, 1.7 and 5.1 mg/l.

The 8-Day EC50 (immobilisation) value based on the mean measured concentrations as a test item for the parental Ceriodaphnia generation (P1) was calculated to be 5.1 mg/l.

The 8-Day EC50 (reproduction) value based on the mean measured concentrations as a test item was calculated to be 3.6 mg/l with 95% confidence limits of 2.0 - 13 mg/l.

The "Lowest Observed Effect Concentration" was considered to be 5.1 mg/l as a test item on the basis that at this test concentration significantly fewer live young per adult (P<0.05) were produced when compared to the control.

The "No Observed Effect Concentration" was considered to be 1.7 mg/l on the basis that at this test concentration there were no significant mortalities (immobilisation) observed in the parental generation (P1) and that there were no significant differences (P≥0.05) between the control and the 1.7 mg/l test group in terms of numbers of live young produced per adult by Day 8.

To obtain the full study, please contact: reach@manganese.org

 

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