General Assembly Meeting Thursday, May 5th 10:00 – 13:00

General Assembly Meeting - 2022

Highlights from the General Assembly Meeting

The 2022 General Assembly meeting which took place virtually on May 5th discussed general issues related to the smooth running of the consortium as well as possible threats emanating from ECHA/the Commission by way of potential Restrictions/Authorisation related to the use of several Mn substances within the EU amongst other things.

The meeting saw the following decisions taken

The GA agreed a on methodology to redistribute income from Non-EU REACH data sales. MARA’s assets in the form of study reports are being sold for the purposes of Non-EU regulatory compliance in the hope of sharing knowledge on the toxicity profile of Mn-based substances in view of a worldwide harmonising the classification. The GA agreed that if the entire industry use the same data – then industry will settle for the same classification.

MARA’s Office: The GA discussed the need of an actual office versus a virtual office from a financial standpoint. Considering that work was still effective during the pandemic lockdown, it was clear that a virtual office will reduce cost without affecting the quality of work carried out by the Consortium. To this end, the GA approved for MARA to seek advice from the French authorities on the possibility of a Not-for-profit organisation to be domicile virtually.

Harmonised Categorization of Slags across the EU: The GA approved a way to fund this special project. The project which considers the present regulatory constraints on the use or disposal of slags across the EU to be non-harmonised is aimed at creating a level playing field guided by a harmonised regulatory standpoint for all players within the EU. The project intends to use a robust socio-economic analysis and lobbying of the authorities to achieve its goes.


Introduction. A study was performed to assess the effect of the test item on the survival and reproduction of Ceriodaphnia dubia over an 8-Day period. The method followed that described in the OECD Guidelines for Testing of Chemicals No 211 (1998) "Daphnia magna, Reproduction Test", US EPA Short-term Methods for Estimating the Chronic Toxicity of Effluents and Receiving Waters to Freshwater Organisms (Method 1002.0) and OPPTS Ecological Effects Test Guideline, Daphnid Chronic Toxicity Test OPPTS 850.1300.


Results. The test item contained a theoretical manganese content of 77% w/w. The test samples were analysed for manganese only. Analysis of the fresh test preparations on Days 0, 2, 5 and 7 showed measured concentrations to range from 0.142 to 7.81 mg/l as test item. Analysis of the old media on Days 2, 5, 7 and 8 showed measured concentrations to range from 0.109 to 7.68 mg/l as test item. The measured concentration of the saturated solution, and hence the prepared dilutions, was observed to increase at each media renewal over the period of the test. A review of the data did not reveal a reason for this but may have been the result of slight changes due to media differences on a day to day basis.


Given that no decline in measured concentration was observed over each media renewal period, the results are based on the mean measured test concentrations as test item only. These were calculated to be 0.40, 1.3 and 4.1 mg/l.


The 8-Day EC50 (immobilisation) value based on the mean measured test concentrations as test item, for the parental Ceriodaphnia generation (P1), was estimated to be 4.1 mg/l.


The 8-Day EC50 (reproduction) value based on the mean measured test concentrations as test item was calculated to be 2.5 mg/l with 95% confidence limits of 2.2 - 2.8 mg/l.


The "Lowest Observed Effect Concentration" was considered to be 4.1 mg/l as test item on the basis that at this test concentration no live young were produced during the test.


The "No Observed Effect Concentration" was considered to be 1.3 mg/l as test item on the basis that at this test concentration there were no significant mortalities (immobilisation) observed in the parental generation (P1) and that there were no significant differences (P≥0.05) between the control and the 1.3 mg/l test group in terms of numbers of live young produced per adult by Day 8.


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