IN VITRO SKIN CORROSION/ SiMn slag (Silicomanganese slag)/ GLP
Introduction: The purpose of this test was to evaluate the corrosivity potential of the test material using the SkinEthic in vitro Reconstituted Human Epidermal (RHE) Model after treatment periods of 3 and 60 minutes. Corrosion is directly related to cytotoxicity in the SkinEthic tissue. Cytotoxicity was determined by the metabolic conversion of the vital dye MTT to formazan by viable cells in the test material treated cultures relative to the negative control. The results were used to make a prediction of the corrosivity potential of the test material. The method was designed to meet the requirements of the following:
- OECD Guidelines for the Testing of Chemicals No. 431 “In Vitro Skin Corrosion: Human Skin Model Test” (adopted 2004)
Conclusion: The test material was considered not to have the potential to be corrosive in vivo.
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