2023 Mn REACH Conference September 26-28th Thon Hotel, City Centre, Brussels

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MARA's 2023 Mn REACH Conference is scheduled to take place on September 26-28 at the Thon Hotel City Centre, Brussels.

Speakers from the Manganese Industry, other Metal Consortia, European Metal Associations and Regulatory Experts will enlighten you on the short-term risks/threats on your businesses as well as your responsibilities under the Evaluation aspect of EU REACH


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TK study in Sprague-Dawley Rats/FeMn slag/EC2004/10/EC/Oral/GLP


The purpose of this study was to assess the toxicokinetics (proof of absorption) of Ferromanganese (FeMn) Slag, a by-product of the production of manganese alloys, in a seven week oral study in Sprague‑Dawley rats.  Three groups, each comprising four males and four females, received FeMn Slag at doses of 10, 100 or 1000 mg/kg/day.  A similarly constituted control group received the vehicle, corn oil, at a volume dose of 5 mL/kg/day. 

During the study, toxicokinetics (proof of absorption), clinical condition, body weight and food consumption investigations were undertaken.


There was no evidence of any significant absorption of the test material.  One intermediate dose male had quantifiable concentrations of aluminium at one and 24 hours post‑dose but, otherwise, the plasma levels of the elements measured (manganese, silicon, aluminium and barium) were all below the limit of quantification.

There were no treatment‑related clinical signs, no unscheduled deaths and no effect on bodyweight and food consumption.




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