ASSESSMENT OF OCULAR IRRITATION POTENTIAL/ MnCO3 (Manganese Carbonate)/ GLP

Introduction. The purpose of this study was to determine the eye irritation potential of the test material using the SkinEthic Reconstituted Human Corneal model (HCE, SkinEthic Laboratories, Nice, France) after a treatment period of 10 minutes. The test is based on the hypothesis that irritant chemicals are able to penetrate the corneal epithelial tissue and are sufficiently cytotoxic to cause cell death.

Results. The relative mean viability of the test material treated tissues after a 10-minute exposure was 98.6%.

It was considered unnecessary to proceed with tissue histopathology.

Conclusion. According to the protocol followed the test material was considered to be a Non-Irritant (NI).

To obtain the full study, please contact: reach@manganese.org